Bacterial infections and antimicrobial therapIES group
(BIAT group)
WELCOME To the
Torrents Lab webpage
Bacterial Infections and antimicrobial therapy group (BIAT)
Dr. Eduard Torrents
RESEARCH LINES and OUR GOALS:
RESEARCH LINES and OUR GOALS:
1. To understand the molecular basis of transcriptional regulation of the different genes involved in the bacterial DNA synthesis.
2. Unravel the molecular mechanisms of bacterial virulence and biofilm formation. To understand the physiology of bacteria growing in a biofilm.
3. New drug delivery systems to kill bacteria living in biofilms - Treatment of chronic bacterial infections.
4. Discovery of new antimicrobial therapies to combat bacterial infections by the application of nanomedicine techniques.
5. Developing new systems to mimic bacterial wound healing infections.
6. To develop bacterial vaccines.
7. Developing phage therapy to treat chronic bacterial infections.
Campo-Pérez, V., Alcàcer-Almansa, J., Julián, E and Torrents, E. (2023). An easy, high-throughput microtiter plate screening assay to quantify and differentiate species in dual-species biofilm. Microorganisms. 11:2244.
Admella, J. and Torrents, E. (2023). Investigating Bacterial Infections in Galleria mellonella Larvae: Insights into Pathogen Dissemination and Behavior. Journal of Invertebrate Pathology. 200:107975.
Alcàcer-Almansa, J., Àlvarez-Puig, J., Arévalo-Jaimes, BV.,Blanco-Cabra, N. and Torrents, E. (2023). Nuevas metodologías basadas en nanotecnología para el tratamiento de las infecciones crónicas. Revista FQ. Revista de la Federación Española de Fibrosis Quística. Vol 93:26-31.
Alba Rubio-Canalejas, A., Pedraz, L., Torrents, E. (2023). ReViTA: A novel in vitro transcription system to study gene regulation. New Biotechnology. 76:41-48.
Rubio-Canalejas, A., Admella, J., Pedraz, L. and Torrents, E. (2023). Pseudomonas aeruginosa nonphosphorylated AlgR induces ribonucleotide reductase expression under oxidative stress infectious conditions. mSystems. 8(2):e01005-22.
Sanmukh, SG., Admella, J., Moya-Andérico, L., Fehér, T., Arévalo-Jaimes, BV., Blanco-Cabra, N and Torrents, E. (2023). Accessing the in vivo efficiency of clinically isolated phages against uropathogenic and invasive biofilm-forming Escherichia coli strains for phage therapy. Cells. 12:344.
Renau-Mínguez, C., Herrero-Abadía, P., Ruiz-Rodriguez, P., Sentandreu, V., Torrents, E., Chiner-Oms, A., Torres-Puente, M., Comas, I., Julián, E. and Coscolla, M. (2023). Genomic analysis of Mycobacterium brumae sustains its nonpathogenic and immunogenic phenotype. Frontiers in Microbiology. 13:982679
Alcàcer-Almansa, J., Arévalo-Jaimes, BV., Blanco-Cabra, N. and Torrents, E. (2023). Methods for studying biofilms: microfluidics and translation into the clinical context. Methods in Microbiology. Biofilm. Vol 53: 195-233.
Rubio-Canalejas, A., Herbera, S., Baelo, A., Blanco-Cabra, N., Vukomanovic, M., Torrents, E. (2022). 3D spatial organization and improved antibiotic treatment of a Pseudomonas aeruginosa - Staphylococcus aureus wound biofilm by nanoparticle enzyme delivery. Frontiers in Microbiology. 13: 959156.
Vukomanovic, M., Gazvoda, L., Kurtjak, M., Hrescak, J., Jaklic, B., Moya-Andérico, L., Cendra, MdM., Torrents, E. (2022). Development of a ternary cyclodextrin–arginine–ciprofloxacin complex with enhanced stability. Communications Biology. 5:1234.
Admella, J. and Torrents, E. (2022). A straightforward method for the isolation and cultivation of Galleria mellonella hemocytes. International Journal of Molecular Sciences. 23: 13483.
García-Díaz, M., Cendra, MdM., Alonso, R., Urdániz, M., Torrents, E. and Martínez, E. (2022). Mimicking the intestinal host-pathogen interactions in a 3D in vitro model: the role of the mucus layer. Pharmaceutics. 14:1552.
Blanco-Cabra, N., Movellan, J., Marradi, M., Gracia, R., Salvador, C., Dupin, D., Loinaz, I., Torrents, E. (2022). Dextran-based single-chain nanoparticles improve the tobramycin and DNase I activity against mature biofilms by interacting with the extracellular matrix. npj Biofilms and Microbiomes. 8:52.
Guallar-Garrido, S., Almiñana-Rapún, F., Campo-Pérez, V., Torrents,E., Luquin, M., and Julián, E. (2022). BCG Substrains Change Their Outermost Surface as a Function of Growth Media. Vaccines 10: 40.
Lozano, H., Millan-Solsona, R., Blanco-Cabra, N., Fabregas, R., Torrents, E., Gomila, G. (2021). Electrical Properties of Outer Membrane Extensions from Shewanella oneidensis MR-1. Nanoscale 13:18754-762.
Vukomanovic, M., Cendra, MdM., Baelo, A. and Torrents, E. (2021). Nano-engineering stable contact-based antimicrobials: chemistry at the interface between nano-gold and bacteria. Colloids and Surfaces B: Biointerfaces. 208: 112083.
Blanco-Cabra, N., López-Martínez, MJ., Arévalo-Jaimes, BV., Martín-Gómez, MT., Samitier, J. and Torrents, E. (2021). A new BiofilmChip device as a personalized solution for testing biofilm antibiotic resistance. npj Biofilms and Microbiomes 7:62.
Cendra, MdM., Torrents, E. (2021). Pseudomonas aeruginosa biofilms and their partners in crime. Biotechnology Advances. 49:107734.
Vilela, D., Blanco-Cabra, N., Eguskiza, A., Hortelao, AC., Torrents, E., Sanchez, S. (2021). Drug-Free Enzyme-Based Bactericidal Nanomotors against Pathogenic Bacteria. ACS Appl. Mater. Interfaces. 13, 13, 14964–14973.
Campo-Pérez, V., Cendra, MdM., Julián, E., Torrents, E. (2021). Easily applicable modifications to electroporation conditions improve the transformation efficiency rates for rough morphotypes of fast-growing mycobacteria. New Biotechnology. 63: 10-18.
Abdelrahman , F., Easwaran, M., Daramola, OI., Ragab, S., Lynch, S., Oduselu, TJ., Khan, FM., Ayobami, A., Adnan, F., Torrents, E., Sanmukh, S. and El-Shibiny, A. (2021). Phage-Encoded Endolysins. Antibiotics. 10: 124.
Moya-Andérico, L., Vukomanovic, M., Cendra, MdM., Segura-Feliu, M., Gil, V., Del Río, JA. and Torrents, E. (2021). Utility of Galleria mellonella larvae for evaluating nanoparticle toxicology. Chemosphere. 266:129235
Moya-Andérico, L., Admella, J. and Torrents, E. (2021). A clearing protocol for Galleria mellonella larvae: visualization of internalized fluorescent nanoparticle. New Biotechnology. 60: 20-26.
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